2-(3-bromo-4-hydroxyphenyl)acetic acid

2-(3-bromo-4-hydroxyphenyl)acetic acid - Names and Identifiers

Name	3-bromo-4-hydroxyphenylacetic acid
Synonyms	3-Bromo-4-hydroxyphenyl 3-bromo-4-hydroxyphenylacetic acid 3-BROMO-4-HYDROXYPHENYLACETIC ACID 3-BROMO-4-HYDROXYBENZENEACETIC ACID Benzeneacetic acid, 3-bromo-4-hydroxy- 2-(3-bromo-4-hydroxyphenyl)acetic acid
CAS	38692-80-7
EINECS	254-089-8
InChI	InChI=1/C8H7BrO3/c9-6-3-5(4-8(11)12)1-2-7(6)10/h1-3,10H,4H2,(H,11,12)

2-(3-bromo-4-hydroxyphenyl)acetic acid - Physico-chemical Properties

Molecular Formula	C8H7BrO3
Molar Mass	231.04
Density	1.757
Melting Point	105-107℃
Boling Point	364℃
Flash Point	174℃
Vapor Presure	6.18E-06mmHg at 25°C
pKa	4.33±0.10(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.632

2-(3-bromo-4-hydroxyphenyl)acetic acid - Risk and Safety

Risk Codes	22 - Harmful if swallowed
Hazard Class	IRRITANT

2-(3-bromo-4-hydroxyphenyl)acetic acid - Introduction

Acid, the chemical formula is C8H7BrO3, is an organic compound. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: acid is a colorless or white crystalline solid.
-Solubility: Soluble in organic solvents such as ethanol, ethers and chloroform, insoluble in water.

Use:
-Chemical synthesis: acid can be used as an organic synthesis intermediate for the synthesis of other organic compounds and drugs.
-Drug development: It can also be used as an important raw material in drug development, for example, for the synthesis of specific classes of antibiotics, anti-inflammatory drugs and analgesic drugs.

Preparation Method:
The preparation method of acid can be carried out by the following steps:
1. Dissolve p-hydroxyphenylacetic acid in dimethylformamide.
2. Add cuprous bromide (Copper(I) bromide) as a catalyst.
3. at low temperature, slowly add acetyl bromide (bromoacetyl bromide).
4. After completion of the reaction, the reaction mixture was diluted with water to precipitate the product.
5. Further steps such as crystallization, filtration and drying are carried out to obtain IACID.

Safety Information:
-the acid needs to pay attention to safety measures during handling and storage. Appropriate skin contact and respiratory precautions should be taken to avoid inhalation of dust or direct contact with skin and eyes.
-When handling this compound, a chemical ventilation system should be used to avoid its adverse effects on the environment and the human body.
-Follow the correct laboratory operation steps and operate according to the chemical safety data sheet.
-the acid should be stored in a dry, well-ventilated place, away from fire and oxidizing agents.
-In the event of accidental inhalation or exposure to the compound, seek immediate medical attention and provide the safety data sheet to a physician for reference.

Last Update：2024-04-09 19:05:49